Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 5/20 | 0.37 |
| ▸ | CASP7 | P55210 | 3/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133818 | 0.82 | MAPT (0.46) | CASP3CASP7CASP9LRRK2RET | |
| SCHEMBL7138414 | 0.77 | SRC (0.49) | CASP3CASP7CASP9SRCLCK | |
| SCHEMBL5366802 | 0.72 | LRRK2 (0.70) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL5368833 | 0.72 | PLK4 (0.60) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL7133855 | 0.71 | ERBB2 (0.53) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL5359476 | 0.71 | ERBB2 (0.61) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL7138324 | 0.71 | RET (0.50) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL7138244 | 0.71 | CCNE1 (0.34) | CASP3CASP7CASP9LRRK2RET | |
| SCHEMBL7133851 | 0.71 | MOGAT2 (0.51) | CASP3CASP7CASP9CASP1 | |
| SCHEMBL5361384 | 0.70 | MDM2 (0.54) | RETPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |