Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820890 | 1.00 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL7488827 | 1.00 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL7122244 | 1.00 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL819549 | 1.00 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL19132495 | 0.93 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL29993610 | 0.93 | POLB (0.45) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL29830276 | 0.93 | POLB (0.45) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL20666655 | 0.91 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL9640980 | 0.91 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL28747 | 0.91 | POLB (0.43) | POLBPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660759-B1 | 4.5-diaryloxazole compounds with prostaglandin I2 (PGI2) agonistic activity | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2003-12-09 | — | — | US | disclosed |
| EP-1208099-A1 | 4,5-DIARYLOXAZOLE COMPOUNDS WITH PROSTAGLANDIN I2 (PGI2) AGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001016132-A1 | 4,5-DIARYLOXAZOLE COMPOUNDS WITH PROSTAGLANDIN 12 (PG12) AGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-08 | — | — | WO | disclosed |