Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359703 | 0.80 | RET (0.37) | KMT2AMEN1 | |
| SCHEMBL5368634 | 0.80 | KMT2A (0.38) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL7139425 | 0.80 | KMT2A (0.49) | MAPTALDH1A1KMT2AMEN1XBP1 | |
| SCHEMBL7135625 | 0.79 | KMT2A (0.42) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL7134045 | 0.79 | KMT2A (0.42) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL7138169 | 0.78 | POLB (0.42) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL7133179 | 0.77 | KMT2A (0.60) | MAPTALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL7135552 | 0.76 | ERBB2 (0.34) | MAPTALDH1A1KMT2AMEN1ALDH2 | |
| SCHEMBL7139869 | 0.75 | PTPN1 (0.43) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7134889 | 0.75 | DYRK1A (0.39) | MAPTALDH1A1KMT2AMEN1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |