Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.50 |
| ▸ | MGAT2 | Q10469 | 3/20 | 0.47 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360936 | 0.83 | MOGAT2 (0.54) | MOGAT2MGAT2TLK2PRKDCAR | |
| SCHEMBL7137514 | 0.83 | SYK (0.52) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL5358796 | 0.83 | NTRK1 (0.65) | MOGAT2MGAT2NTRK1SYKPRKDC | |
| SCHEMBL5362504 | 0.82 | MOGAT2 (0.49) | MOGAT2MGAT2TLK2NTRK1SYK | |
| SCHEMBL7131379 | 0.82 | MOGAT2 (0.57) | MOGAT2MGAT2NTRK1SYKPRKDC | |
| SCHEMBL5366412 | 0.82 | MOGAT2 (0.55) | MOGAT2MGAT2TLK2NTRK1SYK | |
| SCHEMBL5361507 | 0.82 | MOGAT2 (0.55) | MOGAT2MGAT2TLK2NTRK1SYK | |
| SCHEMBL5357745 | 0.82 | MOGAT2 (0.58) | MOGAT2MGAT2PRKDCARPKM | |
| SCHEMBL7138189 | 0.81 | MOGAT2 (0.50) | MOGAT2MGAT2TLK2PRKDCAR | |
| SCHEMBL7132931 | 0.81 | MOGAT2 (0.52) | MOGAT2MGAT2TLK2PRKDCAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |