Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.52 |
| ▸ | PRKDC | P78527 | 4/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 12/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 14/20 | 0.48 |
| ▸ | TEK | Q02763 | 7/20 | 0.48 |
| ▸ | HCK | P08631 | 5/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134981 | 1.00 | ABL1 (0.52) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL5801335 | 0.90 | ABL1 (0.67) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL5803112 | 0.87 | SRC (0.59) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL7703972 | 0.86 | ABL1 (0.62) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL5813561 | 0.79 | ABL1 (0.54) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL4820493 | 0.76 | LCK (0.68) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL14617846 | 0.75 | EGFR (0.60) | KDRPIK3CDEGFRPIK3CAPIK3CG | |
| SCHEMBL4826465 | 0.75 | LCK (0.74) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL4826428 | 0.73 | LCK (0.65) | ABL1KDRPIK3CDEGFRPIK3CA | |
| SCHEMBL4824991 | 0.73 | LCK (0.79) | ABL1EGFRLCKSRCTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |