SCHEMBL7135372

SCHEMBL7135372

CO/C=C(/C(=O)OC)c1ccccc1/C=C/C=C/c1cc(OC)c(OC)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.46
LY96 Q9Y6Y9 2/20 0.41
PRKDC P78527 1/20 0.40
THRB P10828 1/20 0.40
NFE2L2 Q16236 2/20 0.39
AR P10275 2/20 0.39
ABCB1 P08183 2/20 0.39
MAPT P10636 1/20 0.39
MAOB P27338 1/20 0.38
TFEB P19484 1/20 0.38
BACE1 P56817 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7136375 1.00 KDM1A (0.46) KDM1ALY96PRKDCTHRBNFE2L2
SCHEMBL7144515 0.91 KDM1A (0.44) KDM1ALY96PRKDCNFE2L2AR
SCHEMBL7144518 0.91 KDM1A (0.44) KDM1ALY96PRKDCNFE2L2AR
SCHEMBL7135428 0.85 LY96 (0.47) LY96NFE2L2ARMAOBBACE1
SCHEMBL7140111 0.77 AR (0.46) NFE2L2ARMAPTMAOBTFEB
SCHEMBL7136740 0.77 HCAR2 (0.41) NFE2L2ARABCB1MAOBTFEB
SCHEMBL7136721 0.77 HCAR2 (0.41) NFE2L2ARABCB1MAOBTFEB
SCHEMBL7140107 0.77 AR (0.46) NFE2L2ARMAPTMAOBTFEB
SCHEMBL7140046 0.76 MEN1 (0.44) NFE2L2ABCB1MAPTMEN1KMT2A
SCHEMBL7140051 0.76 MEN1 (0.44) NFE2L2ABCB1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0996439-B1 BETA-ALKOXYACRYLATES AGAINST MALARIA HOFFMANN LA ROCHE (CH) 2003-01-08 EP claimed
US-6084120-A ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID HOFFMANN-LA ROCHE INC. (US) 2000-07-04 US claimed
EP-0996439-B1 BETA-ALKOXYACRYLATES AGAINST MALARIA HOFFMANN LA ROCHE (CH) 2003-01-08 EP disclosed
US-6084120-A ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID HOFFMANN-LA ROCHE INC. (US) 2000-07-04 US disclosed