Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12776266 | 0.85 | CYP19A1 (0.50) | CYP19A1DRD1SRD5A1HTR2CDRD2 | |
| SCHEMBL27482346 | 0.80 | PPARD (0.46) | PPARD | |
| SCHEMBL630429 | 0.79 | CYP24A1 (0.57) | CYP19A1HTR2CDRD2 | |
| SCHEMBL1400671 | 0.78 | PPARG (0.53) | CYP19A1DRD1SRD5A1HTR2CPPARD | |
| SCHEMBL1400327 | 0.78 | PPARG (0.53) | CYP19A1DRD1SRD5A1HTR2CPPARD | |
| SCHEMBL12084123 | 0.76 | CHRNA7 (0.48) | CYP19A1DRD1HTR2CCHRNA7 | |
| SCHEMBL8068811 | 0.76 | HTR2C (0.64) | CYP19A1DRD1SRD5A1HTR2CDRD2 | |
| SCHEMBL31525384 | 0.76 | HTR2C (0.64) | CYP19A1DRD1SRD5A1HTR2CDRD2 | |
| SCHEMBL16944438 | 0.76 | HTR2C (0.64) | CYP19A1DRD1SRD5A1HTR2CDRD2 | |
| SCHEMBL28110047 | 0.75 | SRD5A1 (0.51) | CYP19A1DRD1SRD5A1HTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506775-B1 | Treatment of a gastrointestinal disorder; a central nervous system (CNS) adverse conditions caused by Heliobacter pylori; or angiogenesis especially CNS disorders in a mammalian subject, especially humans. | PFIZER INC | 2003-01-14 | — | — | US | disclosed |
| US-6329396-B1 | TREATMENT OF GASTROINTESTINAL DISORDERS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; INFLAMMATORY DISEASE; EMESIS; URINARY INCONTINENCE; PAIN; MIGRAINE; SUNBURN; DISEASES, DISORDERS AND ADVERSE CONDITIONS CAUSED BY HELIOBACTER PYLORI; OR | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0861235-B1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1114817-A1 | Substituted benzylamino piperidine compounds | PFIZER INC. (US) | 2001-07-11 | — | — | EP | disclosed |