Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | FCER2 | P06734 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14674043 | 0.92 | LRRK2 (0.62) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL14674042 | 0.92 | LRRK2 (0.62) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL7136913 | 0.88 | LRRK2 (0.57) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL5369843 | 0.88 | SRC (0.59) | LRRK2SRCCDK2KDRNTRK1 | |
| SCHEMBL7137989 | 0.88 | SRC (0.54) | LRRK2SRCCDK2KDRNTRK1 | |
| SCHEMBL7132147 | 0.86 | SRC (0.55) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL7132123 | 0.86 | SYK (0.62) | LRRK2SRCCDK2KDRNTRK1 | |
| SCHEMBL14674178 | 0.85 | LRRK2 (0.50) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL14674179 | 0.85 | LRRK2 (0.50) | LRRK2SRCCDK2KDRPSEN1 | |
| SCHEMBL7137038 | 0.84 | SYK (0.49) | LRRK2SRCCDK2KDRPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |