Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.77 |
| ▸ | LCK | P06239 | 14/20 | 0.77 |
| ▸ | TEK | Q02763 | 14/20 | 0.77 |
| ▸ | KDR | P35968 | 7/20 | 0.77 |
| ▸ | BTK | Q06187 | 2/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.63 |
| ▸ | IGF1R | P08069 | 6/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.63 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.63 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | PAK4 | O96013 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23847634 | 0.93 | SRC (0.74) | SRCLCKTEKKDRBTK | |
| SCHEMBL23847493 | 0.93 | SRC (0.74) | SRCLCKTEKKDRBTK | |
| SCHEMBL7142942 | 0.90 | SRC (0.70) | SRCLCKTEKKDRBTK | |
| SCHEMBL6430812 | 0.89 | SRC (0.80) | SRCLCKTEKKDRBTK | |
| SCHEMBL6430816 | 0.89 | SRC (0.80) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433761 | 0.88 | SRC (0.73) | SRCLCKTEKKDRBTK | |
| SCHEMBL6431519 | 0.88 | SRC (0.73) | SRCLCKTEKKDRBTK | |
| SCHEMBL6431518 | 0.88 | SRC (0.73) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433764 | 0.88 | SRC (0.73) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433865 | 0.88 | SRC (0.68) | SRCLCKTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |