Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAX | P61244 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364290 | 0.90 | MEN1 (0.44) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL5377214 | 0.87 | FLT3 (0.47) | MEN1KMT2AFLT3RPS6KA3PDPK1 | |
| SCHEMBL7136594 | 0.85 | NPC1 (0.62) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL5361178 | 0.84 | NTRK1 (0.41) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL7139603 | 0.84 | MEN1 (0.49) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL7139419 | 0.83 | MEN1 (0.67) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL14673676 | 0.82 | LRRK2 (0.62) | MEN1KMT2ARPS6KA3LRRK2 | |
| SCHEMBL14673675 | 0.82 | LRRK2 (0.62) | MEN1KMT2ARPS6KA3LRRK2 | |
| SCHEMBL14674037 | 0.81 | MEN1 (0.69) | MEN1KMT2AFLT3NPC1RPS6KA3 | |
| SCHEMBL29638272 | 0.81 | MEN1 (0.69) | MEN1KMT2AFLT3NPC1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |