Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.67 |
| ▸ | LCK | P06239 | 17/20 | 0.67 |
| ▸ | TEK | Q02763 | 17/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.58 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.56 |
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430194 | 0.94 | SRC (0.67) | SRCLCKTEKKDRBTK | |
| SCHEMBL6430198 | 0.94 | SRC (0.67) | SRCLCKTEKKDRBTK | |
| SCHEMBL7136268 | 0.91 | SRC (0.63) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6434796 | 0.91 | SRC (0.61) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6434801 | 0.91 | SRC (0.61) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6437911 | 0.91 | SRC (0.68) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6462695 | 0.91 | SRC (0.68) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6462699 | 0.91 | SRC (0.68) | SRCLCKTEKKDRBTK | |
| Acetic Acid SCHEMBL6437910 | 0.91 | SRC (0.68) | SRCLCKTEKKDRBTK | |
| SCHEMBL6433477 | 0.88 | LCK (0.73) | SRCLCKTEKKDRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |