Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711742 | 0.88 | SCN9A (0.51) | SCN9ASCN3ASCN5ASCN1AKCNH2 | |
| SCHEMBL713543 | 0.87 | SCN9A (0.60) | SCN9ASCN3ASCN5ASCN1AKCNH2 | |
| SCHEMBL714026 | 0.87 | SCN9A (0.53) | SCN9ASCN3ASCN5ASCN1ASCN8A | |
| SCHEMBL711707 | 0.85 | SCN9A (0.51) | SCN9ASCN3ASCN5ASCN1ASCN8A | |
| SCHEMBL712498 | 0.83 | SCN9A (0.51) | SCN9ASCN3ASCN5ASCN1ASCN8A | |
| SCHEMBL709786 | 0.81 | SCN9A (0.49) | SCN9ASCN3ASCN5ASCN1AKCNH2 | |
| SCHEMBL714098 | 0.81 | SCN9A (0.52) | SCN9ASCN3ASCN5ASCN1AKCNH2 | |
| SCHEMBL715219 | 0.79 | SCN9A (0.50) | SCN9ASCN3ASCN5ASCN1ASCN8A | |
| SCHEMBL710922 | 0.79 | SCN9A (0.55) | SCN9ASCN1ASCN8A | |
| SCHEMBL713584 | 0.79 | SCN9A (0.51) | SCN9ASCN3ASCN5AUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | claimed |