Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.66 |
| ▸ | FCER2 | P06734 | 4/20 | 0.66 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.56 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.51 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366318 | 0.89 | SYK (0.51) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL7136077 | 0.84 | SYK (0.78) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL7131379 | 0.83 | MOGAT2 (0.57) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5368255 | 0.83 | MOGAT2 (0.55) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5358796 | 0.82 | NTRK1 (0.65) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5368431 | 0.82 | MOGAT2 (0.55) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5361781 | 0.82 | MOGAT2 (0.51) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5366412 | 0.82 | MOGAT2 (0.55) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5361507 | 0.82 | MOGAT2 (0.55) | SYKNTRK1NTRK3NTRK2FCER2 | |
| SCHEMBL5357745 | 0.81 | MOGAT2 (0.58) | MOGAT2MGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |