Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135626 | 0.88 | MDM2 (0.50) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5366450 | 0.86 | FLT3 (0.50) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5364261 | 0.85 | MDM2 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7139603 | 0.85 | MEN1 (0.49) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5361064 | 0.83 | RAF1 (0.46) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7135240 | 0.82 | KDR (0.44) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5367186 | 0.82 | LRRK2 (0.53) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7133928 | 0.81 | LRRK2 (0.53) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7136250 | 0.81 | RAF1 (0.56) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5373291 | 0.81 | MDM2 (0.55) | LRRK2PDPK1KDRPDGFRBFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |