Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.54 |
| ▸ | CDK7 | P50613 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405756 | 0.86 | ALK (0.56) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL6405753 | 0.86 | ALK (0.56) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5203968 | 0.86 | PDPK1 (0.57) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5203890 | 0.85 | AURKB (0.72) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5469136 | 0.85 | AURKB (0.72) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5841215 | 0.83 | SYK (0.52) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL6403951 | 0.83 | TLK2 (0.55) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5183066 | 0.83 | SYK (0.66) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL5183073 | 0.83 | SYK (0.66) | CDK1CCNB1CDK5CDK5R1CDK7 | |
| SCHEMBL6411135 | 0.83 | TLK2 (0.55) | CDK1CCNB1CDK5CDK5R1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |