Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | APP | P05067 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.59 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | ARAF | P10398 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138013 | 0.95 | MAPT (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7133876 | 0.91 | MAPT (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7132119 | 0.89 | PSEN1 (0.69) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5358413 | 0.84 | RET (0.73) | MAPTAPPLRRK2RAF1RET | |
| SCHEMBL7137717 | 0.83 | PPARG (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7138842 | 0.82 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7132030 | 0.82 | MAPT (0.69) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7132943 | 0.81 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7132904 | 0.80 | MAPT (0.74) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7133810 | 0.80 | MAPT (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |