Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 6/20 | 0.52 |
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | FCER2 | P06734 | 2/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.45 |
| ▸ | YES1 | P07947 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365998 | 0.91 | KDR (0.54) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL5357890 | 0.88 | SRC (0.51) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7132924 | 0.86 | NPC1 (0.60) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL5358525 | 0.85 | SRC (0.51) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7138258 | 0.84 | MEN1 (0.66) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7133821 | 0.84 | KDR (0.56) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7133374 | 0.82 | KDR (0.57) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7131130 | 0.82 | NPC1 (0.63) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL5365875 | 0.81 | SRC (0.51) | KDRCDK2SRCSYKNTRK1 | |
| SCHEMBL7136896 | 0.81 | KDR (0.56) | KDRCDK2SRCSYKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |