Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.51 |
| ▸ | YES1 | P07947 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | FCER2 | P06734 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136883 | 0.87 | SRC (0.58) | SRCCDK2KDRLCKFYN | |
| SCHEMBL5365190 | 0.86 | PSEN1 (0.60) | SRCCDK2KDRPDGFRBAPP | |
| SCHEMBL7136913 | 0.86 | LRRK2 (0.57) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL5369843 | 0.86 | SRC (0.59) | SRCCDK2KDRLCKFYN | |
| SCHEMBL5362182 | 0.86 | RET (0.66) | SRCCDK2KDRLCKFYN | |
| SCHEMBL7140878 | 0.86 | SYK (0.55) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL7130343 | 0.84 | SRC (0.55) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL7135152 | 0.84 | SRC (0.55) | SRCCDK2KDRLCKFYN | |
| SCHEMBL5361448 | 0.84 | SYK (0.65) | SRCCDK2KDRNTRK1FCER2 | |
| SCHEMBL5365022 | 0.84 | SRC (0.55) | SRCCDK2KDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |