Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.57 |
| ▸ | HMGCR | P04035 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 4/20 | 0.37 |
| ▸ | GCGR | P47871 | 3/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9362475 | 0.89 | NR1I2 (0.45) | NR1I2HMGCRIDO1GCGRCAPN1 | |
| SCHEMBL9357630 | 0.87 | NR1I2 (0.43) | NR1I2IDO1GCGRCAPN1CTSL | |
| SCHEMBL19279399 | 0.81 | NR1I2 (0.66) | NR1I2HMGCRMEN1KMT2AKDM4E | |
| SCHEMBL9358736 | 0.80 | HMGCR (0.44) | NR1I2HMGCRIDO1GCGRCAPN1 | |
| SCHEMBL7759881 | 0.78 | NR1I2 (0.54) | NR1I2HMGCRGCGRMEN1KMT2A | |
| SCHEMBL9484666 | 0.77 | IDO1 (0.46) | IDO1GCGRCAPN1CTSLCTSB | |
| SCHEMBL7760639 | 0.77 | NR1I2 (0.53) | NR1I2HMGCRMEN1KMT2APOLB | |
| SCHEMBL6942208 | 0.77 | HMGCR (0.63) | NR1I2HMGCRMEN1KMT2AKDM4E | |
| SCHEMBL7079256 | 0.75 | NR1I2 (0.48) | NR1I2HMGCRMEN1KMT2APOLB | |
| SCHEMBL19398053 | 0.74 | NR1I2 (0.56) | NR1I2HMGCRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0418064-B1 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR SA (CH) | 1994-12-14 | — | — | EP | disclosed |
| US-5204336-A | Anticholestrol agents | SYMPHAR S.A. (CH) | 1993-04-20 | — | — | US | disclosed |
| EP-0418064-A2 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR S.A. (CH) | 1991-03-20 | — | — | EP | disclosed |