Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.58 |
| ▸ | ACE | P12821 | 2/20 | 0.58 |
| ▸ | ECE1 | P42892 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138798 | 1.00 | MME (0.58) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7137022 | 0.90 | ECE1 (0.60) | MMEACEECE1KMT2AMEN1 | |
| SCHEMBL7147041 | 0.90 | ECE1 (0.60) | MMEACEECE1KMT2AMEN1 | |
| SCHEMBL7137021 | 0.90 | ECE1 (0.60) | MMEACEECE1KMT2AMEN1 | |
| SCHEMBL7135749 | 0.87 | KMT2A (0.68) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7142130 | 0.87 | KMT2A (0.68) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7135751 | 0.87 | KMT2A (0.68) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7136598 | 0.82 | ECE1 (0.60) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7136592 | 0.82 | ECE1 (0.60) | MMEACEECE1KMT2AHTT | |
| SCHEMBL7135704 | 0.81 | ECE1 (0.69) | MMEACEECE1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6541638-B2 | (2S,4S)-1-(4-Mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2 -carbonyl)-piperidine-4-carboxylic acid ethyl ester for example; zinc protease inhibitors; for treating diseases associated with vasoconstriction | HOFFMAN-LA ROCHE INC. | 2003-04-01 | — | — | US | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |