Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.70 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137877 | 0.90 | MAPK14 (0.71) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6177992 | 0.89 | MAPK14 (0.73) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6177360 | 0.88 | MAPK14 (0.69) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6176847 | 0.88 | MAPK14 (0.69) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL7138375 | 0.87 | MAPK14 (0.74) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6177919 | 0.87 | MAPK14 (0.74) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6176101 | 0.87 | MAPK14 (0.67) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6178169 | 0.87 | MAPK14 (0.67) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6178365 | 0.86 | MAPK14 (0.72) | MAPK14GSK3BCYP1A2MAPK13MAPK12 | |
| SCHEMBL6178962 | 0.85 | MAPK14 (0.89) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1326848-C | Aminopyrazole derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-07-18 | — | — | CN | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| CN-1331688-A | Aminopyridine Derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-01-16 | — | — | CN | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |