Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404151 | 0.86 | ECE1 (0.50) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5409884 | 0.86 | ECE1 (0.50) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL6818867 | 0.85 | ECE1 (0.52) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5409789 | 0.82 | ECE1 (0.49) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5403972 | 0.82 | ECE1 (0.52) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5407330 | 0.82 | ECE1 (0.49) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL7138828 | 0.82 | ECE1 (0.49) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5406244 | 0.81 | ECE1 (0.46) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5409511 | 0.81 | ECE1 (0.50) | ECE1MMEACEMCOLN3TSHR | |
| SCHEMBL5409505 | 0.81 | ECE1 (0.50) | ECE1MMEACEMCOLN3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |