Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.70 |
| ▸ | PIM1 | P11309 | 3/20 | 0.64 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | CSF1R | P07333 | 1/20 | 0.64 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.64 |
| ▸ | MARK3 | P27448 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | CLK2 | P49760 | 1/20 | 0.64 |
| ▸ | ITK | Q08881 | 1/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138597 | 0.89 | PARP1 (0.80) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7137094 | 0.89 | PARP1 (0.80) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL6383270 | 0.85 | PARP1 (0.51) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7136544 | 0.85 | PARP1 (0.78) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7140624 | 0.83 | PARP1 (0.48) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7141034 | 0.83 | PARP1 (0.72) | PARP1DHODH | |
| SCHEMBL7141806 | 0.83 | PIM1 (0.61) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL3577449 | 0.83 | PIM1 (0.82) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7134234 | 0.83 | PARP1 (1.00) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL7861250 | 0.82 | MGAM (0.56) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509365-B1 | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |