Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 13/20 | 0.73 |
| ▸ | F2 | P00734 | 12/20 | 0.73 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.73 |
| ▸ | F10 | P00742 | 10/20 | 0.71 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.59 |
| ▸ | F3 | P13726 | 2/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.59 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140785 | 1.00 | F7 (0.73) | F7F2PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8114466 | 0.99 | F7 (0.72) | F7F2PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8124067 | 0.94 | F2 (0.72) | F7F2PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8122723 | 0.93 | F2 (0.70) | F7F2PRSS1F10PRSS2 | |
| SCHEMBL8124071 | 0.92 | F2 (0.69) | F7F2PRSS1F10PRSS2 | |
| Acetic Acid SCHEMBL8127343 | 0.92 | F7 (0.69) | F7F2PRSS1F10PRSS2 | |
| SCHEMBL7146603 | 0.92 | F7 (0.71) | F7F2PRSS1F10PRSS2 | |
| SCHEMBL7140873 | 0.92 | F2 (0.71) | F7F2PRSS1F10PRSS2 | |
| SCHEMBL7143724 | 0.92 | F7 (0.71) | F7F2PRSS1F10PRSS2 | |
| SCHEMBL7150813 | 0.91 | F2 (0.70) | F7F2PRSS1F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |