Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139003 | 0.96 | ERBB2 (0.48) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7134258 | 0.92 | ERBB2 (0.45) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7135676 | 0.92 | ERBB2 (0.45) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7134059 | 0.88 | SIRT2 (0.49) | ERBB2EGFRPPARGPTPN1SIRT2 | |
| SCHEMBL5363012 | 0.87 | ERBB2 (0.56) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7133930 | 0.87 | PPARG (0.42) | ERBB2EGFRPPARGPTPN1SIRT2 | |
| SCHEMBL5376920 | 0.85 | ERBB2 (0.56) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7132027 | 0.83 | ERBB2 (0.60) | ERBB2EGFRIGF1RSIRT2TDP1 | |
| SCHEMBL5374088 | 0.83 | ERBB2 (0.53) | ERBB2EGFRIGF1RPPARGPTPN1 | |
| SCHEMBL7138210 | 0.82 | PPARG (0.60) | EGFRPPARGPTPN1SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |