SCHEMBL7141252

SCHEMBL7141252

Cc1cc(F)c(F)c(F)c1C=O

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.35
CYP3A4 P08684 3/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
MAPT P10636 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA13 Q8N1Q1 1/20 0.32
USP2 O75604 1/20 0.32
RAPGEF4 Q8WZA2 1/20 0.31
POLB P06746 1/20 0.30
CES2 O00748 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4746715 0.82 ERN1 (0.35) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL1349494 0.82 CYP3A4 (0.38) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL11763496 0.80 CYP3A4 (0.37) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL14035175 0.78 CYP3A4 (0.46) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL10497746 0.78 CA1 (0.41) ERN1CYP3A4CYP2C9CYP2C19CA12
SCHEMBL6454141 0.77 CYP3A4 (0.41) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL21378953 0.77 ERN1 (0.33) ERN1CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL1816310 0.76 ERN1 (0.40) ERN1CA12CA1CA2CA7
SCHEMBL28767076 0.75 ERN1 (0.41) ERN1CYP3A4MAPTPOLB
SCHEMBL28765608 0.74 CYP3A4 (0.38) ERN1CYP3A4MAPTCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1310510-A2 Topologically segregated, encoded solid phase libraries SELECTIDE CORPORATION (US) 2003-05-14 EP claimed
WO-2000053313-A2 LANTHANIDE CATALYSTS FOR SYNTHESIS OF COMPOUNDS AND COMBINATORIAL LIBRARIES ARQULE, INC. (US) 2000-09-14 WO disclosed
WO-1998010286-A1 METHODS FOR PROCESSING CHEMICAL COMPOUNDS HAVING REACTIVE FUNCTIONAL GROUPS ISIS PHARMACEUTICALS, INC. (US) 1998-03-12 WO disclosed
EP-0661978-A1 ARYLMETHYLPHOSPHONATES AND PHOSPHONIC ACIDS USEFUL AS ANTI-INFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY (US) 1995-07-12 EP disclosed
WO-1994007501-A1 ARYLMETHYLPHOSPHONATES AND PHOSPHONIC ACIDS USEFUL AS ANTI-INFLAMMATORY AGENTS THE UPJOHN COMPANY (US) 1994-04-14 WO disclosed