Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 20/20 | 0.74 |
| ▸ | RARG | P13631 | 20/20 | 0.74 |
| ▸ | RARA | P10276 | 17/20 | 0.74 |
| ▸ | RXRA | P19793 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523001 | 0.86 | RARB (0.55) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL8101913 | 0.86 | RARB (0.53) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL7829468 | 0.85 | RARB (1.00) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10551195 | 0.85 | RARB (1.00) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL7829470 | 0.85 | RARB (1.00) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL8459845 | 0.83 | STAT3 (0.62) | RARBRARGRARANPC1ALDH1A1 | |
| SCHEMBL4421853 | 0.81 | KDM4E (0.50) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL9817651 | 0.78 | RARB (0.53) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8460517 | 0.78 | RARB (0.83) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL8460515 | 0.78 | RARB (0.83) | RARBRARGRARARXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586460-B1 | Administering heterocyclic ethers or sulfides to induce apoptosis, cell differentiation and as anticarcinogenic agents | THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY | 2003-07-01 | — | — | US | disclosed |
| EP-0907646-B1 | DIHYDROBENZOPYRAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIV VANDERBILT (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6110960-A | FOR TREATING ARTHRITIS AND AS ANALGESIC | THE PROCTER & GAMBLE COMPANY (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0907646-A1 | DIHYDROBENZOPYRAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1998007716-A2 | HETEROAROTINOIDS-ANTICANCER AGENTS WITH RECEPTOR SPECIFICITY AND TGASE ACTIVITY | THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY (US) | 1998-02-26 | — | — | WO | disclosed |
| WO-1997046548-A1 | DIHYDROBENZOPYRAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY (US) | 1997-12-11 | — | — | WO | disclosed |
| US-4826984-A | Heteroarotinoid compounds as anticancer agents | THE BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGE ACTING FOR AND ON BEHALF OF OKLAHOMA STATE UNIVERSITY (US) | 1989-05-02 | — | — | US | disclosed |