Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21970972 | 0.83 | HPGD (0.53) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL2394908 | 0.81 | HPGD (0.54) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL6152125 | 0.80 | HPGD (0.50) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL24170528 | 0.80 | HPGD (0.50) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL408862 | 0.79 | HPGD (0.58) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL22648878 | 0.78 | HPGD (0.51) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL25173198 | 0.78 | HPGD (0.51) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL21783713 | 0.78 | HPGD (0.48) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL32671892 | 0.77 | HPGD (0.57) | HPGDGPR119RECQLEPHX1KDM4E | |
| SCHEMBL21579340 | 0.77 | HPGD (0.47) | HPGDGPR119RECQLEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |