Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | EED | O75530 | 1/20 | 0.47 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.47 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.47 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | MMP7 | P09237 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4612534 | 0.85 | HPGD (0.53) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL19560047 | 0.85 | HPGD (0.55) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL21995290 | 0.84 | HPGD (0.49) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL1422213 | 0.84 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL7493781 | 0.84 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL387237 | 0.83 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL4523020 | 0.83 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL470530 | 0.83 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL20600888 | 0.83 | HPGD (0.54) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL570862 | 0.83 | NR1H2 (0.47) | HPGDGPR119RECQLEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5726185-A | BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELET AGGREGATION AND CELL TO CELL ADHESION | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |