Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179169 | 0.93 | MAPK14 (0.63) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL6176832 | 0.91 | MAPK14 (0.63) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL6177029 | 0.89 | MAPK14 (0.59) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL7137615 | 0.88 | MAPK14 (0.58) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL6178768 | 0.88 | MAPK14 (0.58) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL4343331 | 0.88 | MAPK14 (0.71) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL6180262 | 0.86 | MAPK14 (0.56) | MAPK14PRKACAROCK1ALDH1A1WNT3A | |
| SCHEMBL6181393 | 0.86 | MAPK14 (0.56) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL4337064 | 0.86 | MAPK14 (0.57) | MAPK14PRKACAROCK1KDM4ECSNK1D | |
| SCHEMBL6179223 | 0.85 | MAPK14 (0.55) | MAPK14CACNA1HCACNA1GCACNA1IPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |