Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.57 |
| ▸ | F7 | P08709 | 8/20 | 0.57 |
| ▸ | F10 | P00742 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146130 | 0.95 | F2 (0.57) | F2PRSS1F7F10KDM4E | |
| SCHEMBL7146126 | 0.95 | F2 (0.57) | F2PRSS1F7F10KDM4E | |
| SCHEMBL7145663 | 0.93 | F2 (0.52) | F2PRSS1F7F10KDM4E | |
| SCHEMBL5883284 | 0.92 | F2 (0.54) | F2PRSS1F7F10KDM4E | |
| SCHEMBL7147573 | 0.87 | F2 (0.74) | F2PRSS1F7F10KDM4E | |
| SCHEMBL7140382 | 0.87 | F2 (0.49) | F2PRSS1F7F10MAPT | |
| SCHEMBL7150884 | 0.87 | F2 (0.61) | F2PRSS1F7F10KDM4E | |
| SCHEMBL7144188 | 0.86 | F7 (0.58) | F2PRSS1F7F10KDM4E | |
| Acetic Acid SCHEMBL8129058 | 0.86 | F2 (0.72) | F2PRSS1F7F10KDM4E | |
| SCHEMBL8115021 | 0.85 | F7 (0.48) | F2PRSS1F7F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |