Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734028 | 0.94 | ERN1 (0.46) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL3966538 | 0.89 | ERN1 (0.50) | ERN1TLR2TLR1TLR6MAOA | |
| SCHEMBL3967846 | 0.80 | ERN1 (0.47) | ERN1TLR2TLR1TLR6 | |
| SCHEMBL7091474 | 0.79 | CNR2 (0.47) | ERN1TLR2TLR1TLR6 | |
| SCHEMBL27614250 | 0.79 | ERN1 (0.46) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL29658267 | 0.79 | ERN1 (0.50) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL27595415 | 0.79 | ERN1 (0.50) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL7170981 | 0.78 | PPARG (0.40) | ERN1TLR2TLR1TLR6MAOA | |
| SCHEMBL24720517 | 0.78 | TLR8 (0.45) | ALDH1A1HSD17B1HSD17B2MCL1PTGS2 | |
| SCHEMBL7170990 | 0.77 | MCL1 (0.44) | ERN1MCL1PTGS2PTGS1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244446-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1244446-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001039773-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-07 | — | — | WO | disclosed |