Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GFER | P55789 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266259 | 0.99 | MAPT (0.39) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3059729 | 0.97 | MAPT (0.38) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6401036 | 0.97 | MAPT (0.38) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Iodide SCHEMBL2535918 | 0.97 | MAPT (0.38) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2537925 | 0.97 | MAPT (0.38) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6405830 | 0.96 | MAPT (0.37) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Bromide SCHEMBL2538000 | 0.88 | MAPT (0.42) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| SCHEMBL2929917 | 0.87 | MAPT (0.41) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5246554 | 0.87 | ESRRG (0.32) | MAPTGFERKDM4EGAASMN1; SMN2 | |
| SCHEMBL2929100 | 0.86 | MAPT (0.40) | MAPTGFERKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521761-B2 | For coloring hair | CLAIROL INCORPORATED | 2003-02-18 | — | — | US | disclosed |
| US-6461391-B1 | Primary intermediates for oxidative coloration of hair | CLAIROL INCORPORATED | 2002-10-08 | — | — | US | disclosed |