Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | QDPR | P09417 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | FABP7 | O15540 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26560458 | 0.87 | HTR1D (0.43) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL27962016 | 0.79 | HTR1D (0.40) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL4772120 | 0.79 | HTR2C (0.46) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL14320398 | 0.79 | BACE1 (0.42) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL14183094 | 0.79 | MAPK14 (0.48) | MAPK14PIK3CDPIK3CAHTR1DBACE1 | |
| SCHEMBL24196019 | 0.79 | HTR1D (0.40) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL24196034 | 0.79 | MAPK14 (0.40) | MAPK14PIK3CDPIK3CAHTR1DDYRK1A | |
| SCHEMBL18857842 | 0.78 | MAPK14 (0.47) | MAPK14PIK3CDPIK3CAHTR1DCSNK1D | |
| SCHEMBL420951 | 0.77 | IKBKE (0.44) | PIK3CDPIK3CAIKBKETBK1FABP7 | |
| SCHEMBL23956483 | 0.77 | HTR1D (0.42) | MAPK14PIK3CDPIK3CAQDPRHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177327-A1 | SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2019-06-13 | — | — | US | disclosed |
| CN-1210250-C | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2005-07-13 | — | — | CN | disclosed |
| EP-1192122-B1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| US-6482986-B1 | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-11-19 | — | — | US | disclosed |
| CN-1355782-A | Benzene derivatives, preparation method and pharmaceutical compositions containing same | SANOFI SYNTHELABO (FR) | 2002-06-26 | — | — | CN | disclosed |
| EP-1192122-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076953-A1 | BENZENE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177327-A1 | SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS | PDE3A, PDE5A, PDE4A | MAPK14 1356/4885PIK3CD 607/4885PIK3CA 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.