Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143232 | 1.00 | GRM2 (0.42) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL32677595 | 0.89 | POLB (0.39) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL31124089 | 0.89 | POLB (0.39) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL12763447 | 0.81 | POLB (0.38) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL7149080 | 0.81 | GRM8 (0.39) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL6463005 | 0.81 | GRM8 (0.39) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL31509784 | 0.75 | GRM2 (0.50) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL3152724 | 0.74 | — | — | |
| SCHEMBL26342285 | 0.74 | — | — | |
| SCHEMBL13539670 | 0.72 | POLB (0.35) | GRM2GRM3GRM8POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6504052-B1 | 2-carboxycyclopropyl glycine derivatives, used as agonists of glutamate receptors for prophylaxis of psychological and nervous system disorders; anxiolytics; antidepressants; drug abuse; anticonvulsant, analgesic and antiemetic agents | ELI LILLY AND COMPANY | 2003-01-07 | — | — | US | disclosed |
| US-6503893-B2 | Anticarcinogenic agents | BONE CARE INTERNATIONAL, INC. | 2003-01-07 | — | — | US | disclosed |