Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 0.62 |
| ▸ | MME | P08473 | 2/20 | 0.62 |
| ▸ | ACE | P12821 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143261 | 0.91 | ECE1 (0.64) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7141766 | 0.90 | ECE1 (0.60) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7141764 | 0.90 | ECE1 (0.60) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7140077 | 0.89 | ECE1 (0.49) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7141127 | 0.88 | ECE1 (0.68) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7141132 | 0.88 | ECE1 (0.68) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7137883 | 0.86 | ECE1 (0.47) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7148294 | 0.85 | ECE1 (0.58) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7148295 | 0.85 | ECE1 (0.58) | ECE1MMEACEALDH1A1HTT | |
| SCHEMBL7135704 | 0.84 | ECE1 (0.69) | ECE1MMEACEALDH1A1CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | claimed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | claimed |