Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 11/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149746 | 0.97 | LSS (0.70) | LSSATML3MBTL1RAB9ASLC6A2 | |
| SCHEMBL5040053 | 0.88 | LSS (0.80) | LSSATML3MBTL1RAB9ASLC6A2 | |
| SCHEMBL5038906 | 0.88 | LSS (0.83) | LSSATML3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL5038468 | 0.88 | LSS (0.83) | LSSATML3MBTL1 | |
| SCHEMBL5038908 | 0.87 | LSS (0.81) | LSSATML3MBTL1KDM4E | |
| SCHEMBL5039989 | 0.85 | LSS (1.00) | LSSATML3MBTL1KDM4E | |
| SCHEMBL5043337 | 0.85 | LSS (0.75) | LSSRAB9AHRH2HRH1 | |
| SCHEMBL5040101 | 0.85 | LSS (0.72) | LSSRAB9AKDM4EHRH2HRH1 | |
| SCHEMBL5045347 | 0.85 | LSS (0.78) | LSSATML3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL5039805 | 0.85 | LSS (0.78) | LSSATML3MBTL1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |