Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146095 | 0.89 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8212173 | 0.87 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DP2RX7 | |
| SCHEMBL7143466 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7143463 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7144718 | 0.83 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7144832 | 0.82 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7151018 | 0.82 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7145904 | 0.79 | PDE4D (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7150885 | 0.78 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8203861 | 0.77 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |
| US-6051718-A | A PHOSPHODIESTERASE ENZYME INHIBITOR AND A CYTOKINE ANTAGONIST FOR TREATING ALLERGIC, ATOPIC AND INFLAMMATORY DISEASES INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-04-18 | — | — | US | disclosed |