Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143634 | 1.00 | HTR2C (0.38) | HTR2CL3MBTL1HTR2AHTR2BHRH3 | |
| SCHEMBL7138486 | 0.85 | TNKS2 (0.36) | KDM1AMEN1GAAMAPTKMT2A | |
| SCHEMBL7142182 | 0.83 | PRCP (0.44) | HTR2CHTR2AHTR2BHRH3GAA | |
| SCHEMBL7142187 | 0.83 | PRCP (0.44) | HTR2CHTR2AHTR2BHRH3GAA | |
| SCHEMBL7138440 | 0.82 | PRCP (0.38) | ALDH1A1MEN1GAAMAPTKMT2A | |
| SCHEMBL7144064 | 0.81 | MEN1 (0.39) | KDM1AMEN1KMT2AKIF11 | |
| SCHEMBL4273307 | 0.81 | PRCP (0.45) | KDM1AALDH1A1MEN1GAAMAPT | |
| SCHEMBL7143821 | 0.80 | KDM1A (0.37) | KDM1AALDH1A1GAAMAPTKMT2A | |
| SCHEMBL7145701 | 0.80 | PRCP (0.44) | HTR2CHTR2AHTR2BHRH3GAA | |
| SCHEMBL7143820 | 0.80 | KDM1A (0.37) | KDM1AALDH1A1GAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966464-B1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-05-28 | — | — | EP | disclosed |
| CN-1091109-C | Substituted 2, 4-diaminopyrimidines | BASLIER PHARMACEUTICALS AG (CH) | 2002-09-18 | — | — | CN | disclosed |
| US-6114330-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| CN-1249751-A | Substituted 2, 4-diaminopyrimidines | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | CN | disclosed |
| EP-0966464-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998039328-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-09-11 | — | — | WO | disclosed |