Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | ECE1 | P42892 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140421 | 0.92 | MME (0.53) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7140418 | 0.92 | MME (0.53) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7141121 | 0.83 | ECE1 (0.66) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7146637 | 0.80 | MME (0.49) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7150245 | 0.79 | MME (0.45) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7148898 | 0.79 | MME (0.40) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7149006 | 0.79 | MME (0.45) | MMEACEECE1LMNAALDH1A1 | |
| SCHEMBL7146031 | 0.79 | ECE1 (0.70) | MMEACEECE1ALDH1A1GAA | |
| SCHEMBL7143562 | 0.79 | ECE1 (0.70) | MMEACEECE1ALDH1A1GAA | |
| SCHEMBL7135602 | 0.79 | MME (0.43) | MMEACEECE1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303485-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006222-A1 | PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |