⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763993 | 0.80 | — | — | |
| SCHEMBL26187546 | 0.72 | — | — | |
| SCHEMBL7858703 | 0.69 | TSHR (0.30) | — | |
| SCHEMBL252367 | 0.69 | TSHR (0.30) | — | |
| SCHEMBL7262903 | 0.69 | TSHR (0.30) | — | |
| Hydrochloric Acid SCHEMBL25380883 | 0.68 | — | — | |
| SCHEMBL7986021 | 0.68 | TSHR (0.32) | — | |
| SCHEMBL17861062 | 0.67 | — | — | |
| SCHEMBL3624139 | 0.66 | — | — | |
| SCHEMBL11022203 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1984921-B | Modulation of survivin expression | ISIS PHARMACEUTICALS INC | 2010-06-16 | — | — | CN | disclosed |
| CN-100558893-C | The adjusting that eIF4E expresses | ISIS PHARMACEUTICALS INC ELI L (US) | 2009-11-11 | — | — | CN | disclosed |
| CN-1984921-A | Modulation of survivin expression | ISIS PHARMACEUTICALS INC (US) | 2007-06-20 | — | — | CN | disclosed |
| CN-1914335-A | Antisense oligonucleotide modulation of STAT3 expression | ISIS PHARMACEUTICALS INC (US) | 2007-02-14 | — | — | CN | disclosed |
| CN-1852979-A | Modulation of eIF4E expression | ISIS PHARMACEUTICALS INC (US) | 2006-10-25 | — | — | CN | disclosed |
| WO-2003048315-A2 | ANTISENSE MODULATION OF MDM2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| EP-1030935-A4 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN SERINE/THREONINE PROTEIN PHOSPHATASE GENE EXPRESSION | UNIV SOUTH ALABAMA (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1185696-A1 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN PROTEIN KINASE C-DELTA EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000070091-A1 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN PROTEIN KINASE C-δ EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2000-11-23 | — | — | WO | disclosed |
| EP-1030935-A1 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN SERINE/THREONINE PROTEIN PHOSPHATASE GENE EXPRESSION | South Alabama Medical Science Foundation (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999027134-A1 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN SERINE/THREONINE PROTEIN PHOSPHATASE GENE EXPRESSION | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 1999-06-03 | — | — | WO | disclosed |
| CN-1187197-A | Antisense oligonucleotide modulation of raf gene expression | ISIS PHARMACEUTICALS INC (US) | 1998-07-08 | — | — | CN | disclosed |