Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.39 |
| ▸ | PDE4A | P27815 | 14/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144717 | 1.00 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7144718 | 0.88 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7417737 | 0.84 | PDE4B (0.37) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7143466 | 0.82 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7143463 | 0.82 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7417732 | 0.79 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7142709 | 0.77 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7146075 | 0.76 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7146082 | 0.76 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7150876 | 0.73 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934280-B1 | PDE IV INHIBITING 2-CYANOIMINOIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-09 | — | — | EP | disclosed |