Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 18/20 | 0.82 |
| ▸ | F2 | P00734 | 16/20 | 0.82 |
| ▸ | F10 | P00742 | 15/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.82 |
| ▸ | F3 | P13726 | 12/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.67 |
| ▸ | F11 | P03951 | 8/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145057 | 1.00 | F7 (0.82) | F7F2F10PRSS1F3 | |
| SCHEMBL7145061 | 1.00 | F7 (0.82) | F7F2F10PRSS1F3 | |
| SCHEMBL7150811 | 0.92 | F2 (0.82) | F7F2F10PRSS1F3 | |
| SCHEMBL7150803 | 0.92 | F2 (0.82) | F7F2F10PRSS1F3 | |
| SCHEMBL7150807 | 0.92 | F2 (0.82) | F7F2F10PRSS1F3 | |
| SCHEMBL7143452 | 0.90 | F7 (1.00) | F7F2F10PRSS1F3 | |
| SCHEMBL7143455 | 0.90 | F7 (1.00) | F7F2F10PRSS1F3 | |
| SCHEMBL7143460 | 0.90 | F7 (1.00) | F7F2F10PRSS1F3 | |
| SCHEMBL5882886 | 0.90 | F7 (0.81) | F7F2F10PRSS1F3 | |
| Hydrochloric Acid SCHEMBL8123157 | 0.90 | F7 (0.98) | F7F2F10PRSS1F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | claimed |
| EP-0921116-B1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | EP | disclosed |
| US-6140353-A | USED AS MEDICAMENTS FOR THE TREATMENT AND/OR PREVENTION OF THROMBOSES, APOPLEXY, CARDIAC INFARCTION, INFLAMMATION AND ARTERIOSCLEROSIS OR AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0921116-A1 | N-(4-carbamimido-phenyl)-glycine amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |