Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145190 | 0.88 | FLT3 (0.37) | BRAFFLT3TYRO3MERTKGAS6 | |
| SCHEMBL7089224 | 0.72 | TP53 (0.49) | BRAFFLT3TYRO3MERTKGAS6 | |
| SCHEMBL7647047 | 0.70 | FLT3 (0.45) | BRAFFLT3TYRO3MERTKGAS6 | |
| SCHEMBL7145186 | 0.69 | FLT3 (0.43) | BRAFFLT3TYRO3MERTKGAS6 | |
| SCHEMBL30794720 | 0.65 | BRAF (0.47) | BRAF | |
| SCHEMBL2131408 | 0.65 | BRAF (0.47) | BRAF | |
| SCHEMBL29019 | 0.64 | CTNNB1 (0.47) | BRAFTP53 | |
| SCHEMBL1721933 | 0.64 | S1PR3 (0.39) | — | |
| SCHEMBL6990055 | 0.63 | TP53 (0.50) | BRAFTP53RXFP1 | |
| SCHEMBL7602331 | 0.63 | TP53 (0.50) | BRAFTP53RXFP1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1361879-A1 | 2,4-DISUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066036-A1 | 2,4-DISUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-29 | — | — | WO | disclosed |