Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 4/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407110 | 1.00 | ECE1 (0.36) | ECE1GPR119DPP4CYP3A4KCNH2 | |
| SCHEMBL5411748 | 0.88 | ECE1 (0.34) | ECE1DPP4CYP2D6DPP8DPP9 | |
| SCHEMBL5405161 | 0.88 | ECE1 (0.36) | ECE1DPP4CYP2D6DPP8DPP9 | |
| SCHEMBL5409820 | 0.88 | ECE1 (0.36) | ECE1DPP4CYP2D6DPP8DPP9 | |
| SCHEMBL5404059 | 0.87 | ECE1 (0.35) | ECE1 | |
| SCHEMBL7139606 | 0.84 | ECE1 (0.33) | ECE1 | |
| SCHEMBL5409498 | 0.84 | ECE1 (0.33) | ECE1 | |
| SCHEMBL5422677 | 0.83 | ECE1 (0.33) | ECE1DPP4HTR2CSLC6A4HTR2A | |
| SCHEMBL5405407 | 0.82 | ECE1 (0.32) | ECE1 | |
| SCHEMBL5401352 | 0.82 | ECE1 (0.32) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | claimed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | claimed |
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | disclosed |