Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.73 |
| ▸ | HRH2 | P25021 | 1/20 | 0.73 |
| ▸ | HTR1D | P28221 | 1/20 | 0.73 |
| ▸ | HTR2A | P28223 | 1/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784160 | 1.00 | HRH3 (0.77) | HRH3KCNH2CHRM2CHRM4HTR1A | |
| SCHEMBL7143762 | 0.90 | HRH3 (0.75) | HRH3KCNH2CHRM2CHRM4HTR1A | |
| SCHEMBL2787430 | 0.90 | HRH3 (0.75) | HRH3KCNH2CHRM2CHRM4HTR1A | |
| SCHEMBL2786108 | 0.90 | HRH3 (0.78) | HRH3KCNH2 | |
| SCHEMBL2786825 | 0.89 | HRH3 (0.77) | HRH3KCNH2 | |
| SCHEMBL2784366 | 0.88 | HRH3 (0.73) | HRH3KCNH2CHRM2CHRM4HTR1A | |
| SCHEMBL2785196 | 0.87 | HRH3 (0.65) | HRH3KCNH2CHRM2CHRM4HTR1A | |
| SCHEMBL2784890 | 0.87 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL7138355 | 0.87 | HRH3 (0.74) | HRH3KCNH2 | |
| SCHEMBL2786130 | 0.87 | HRH3 (0.74) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370546-A2 | NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074758-A2 | NOVEL AMINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-09-26 | — | — | WO | disclosed |