Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404248 | 0.84 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| Hydrochloric Acid SCHEMBL4401516 | 0.83 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4400368 | 0.79 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4396217 | 0.79 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2MAPTUSP2 | |
| SCHEMBL4402583 | 0.79 | SYK (0.52) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| Hydrochloric Acid SCHEMBL4400295 | 0.78 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2MAPTUSP2 | |
| Hydrochloric Acid SCHEMBL4395484 | 0.78 | KMT2A (0.45) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL6958477 | 0.78 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL6957502 | 0.78 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL4400326 | 0.77 | KLKB1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318149-A1 | Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing them | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2003-06-11 | — | — | EP | disclosed |