Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026762 | 1.00 | MAPT (0.53) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5089316 | 0.91 | GSK3B (0.48) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7026103 | 0.90 | GSK3B (0.45) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5089343 | 0.89 | MAPT (0.49) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL27559770 | 0.88 | GSK3B (0.44) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6639575 | 0.87 | GSK3B (0.44) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL27541731 | 0.87 | KMT2A (0.48) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL27559775 | 0.87 | GSK3B (0.48) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL7152632 | 0.85 | GSK3B (0.46) | MAPTSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL5092032 | 0.85 | GSK3B (0.44) | MAPTSMN1; SMN2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |