Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 9/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039999 | 0.87 | LSS (0.70) | LSSCACNA1BAURKAAURKBMAOA | |
| SCHEMBL5038318 | 0.80 | LSS (0.55) | LSSCACNA1BAURKAAURKBMAOA | |
| SCHEMBL5038288 | 0.77 | LSS (0.55) | LSSCACNA1BAURKAAURKBMAOA | |
| SCHEMBL5045545 | 0.74 | LSS (0.81) | LSSAURKAAURKBMAOAMAOB | |
| SCHEMBL5040045 | 0.71 | LSS (0.75) | LSSAURKAAURKBMAOAMAOB | |
| SCHEMBL5043374 | 0.71 | LSS (0.82) | LSSMAOB | |
| SCHEMBL5040098 | 0.71 | LSS (0.82) | LSS | |
| SCHEMBL7149728 | 0.71 | LSS (0.41) | LSS | |
| SCHEMBL5039981 | 0.70 | LSS (0.71) | LSS | |
| SCHEMBL5038937 | 0.69 | LSS (0.82) | LSSMAOBEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334094-A1 | CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036584-A1 | CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-10 | — | — | WO | disclosed |