Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.77 |
| ▸ | PDE4A | P27815 | 19/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209516 | 1.00 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7146993 | 1.00 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7147501 | 0.87 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7147505 | 0.87 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6491057 | 0.87 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7147508 | 0.87 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7136848 | 0.87 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7136851 | 0.87 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7136855 | 0.87 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6866218 | 0.84 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971901-B1 | PHTHALAZINONES | ALTANA PHARMA AG (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-6103718-A | Phthalazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-08-15 | — | — | US | disclosed |
| EP-0971901-A1 | PHTHALAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998031674-A1 | PHTHALAZINONES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-07-23 | — | — | WO | disclosed |